Xinhua News Agency, Beijing, February 20th Question: Let "rare diseases" no longer be "orphans"-What is the expectation of "one pill" for patients with major diseases?

Xinhua News Agency reporters Xiao Sisi, Liao Jun, Bao Xiaojing and Lin Miaomiao

Following the price reduction of some anticancer drugs and medical insurance, "ensuring the use of drugs for 20 million patients with rare diseases" was put on the agenda and attracted much attention. Recently, the State Council held an executive meeting to deploy measures to strengthen the early diagnosis and treatment of cancer and drug security, and decided to give VAT concessions to rare drugs.

From frequently-occurring and common diseases to rare and difficult diseases, the state has played a "combination boxing" to meet the expectations of patients with major diseases for "one pill".

Prevention and treatment of rare diseases play a "combination boxing"

Rare diseases are often called "medical orphans" because of their few clinical cases and little experience, which leads to high misdiagnosis, high missed diagnosis and difficult medication.

Feifei, a two-year-old boy from Hefei, Anhui, suffers from "painless anhidrosis". He often bites his fingers until they are bloody and pulls out his four teeth with his hands, but there is no pain. There are only about 100 cases of this rare disease in the world.

Feifei’s "painless anhidrosis" is one of the more than 7,000 rare diseases confirmed at present. According to the definition of the World Health Organization, rare diseases refer to diseases in which the number of patients accounts for 0.65 ‰-1 ‰ of the total population, including gradual freezing, "glass man" (hemophilia), "puppet man" (multiple sclerosis), involuntary dancing (Huntington’s disease), limp children (spinal muscular atrophy), PNH (paroxysmal nocturnal hemoglobinuria) and so on. In fact, rare diseases are not rare. There are more than 7,000 rare diseases, and the total number of patients with all rare diseases in China has reached more than 20 million …

Pan Longfei, 30, is a patient with Kalman syndrome. This is a rare hereditary disease. Because of hypogonadism, patients suffer from hypoplasia or loss of secondary sexual characteristics, in addition to the loss of sense of smell.

"I was diagnosed at the age of 23." Pan Longfei said that since he was a child, he was thinner and sicker than others. From the age of 6, his parents took him everywhere for medical advice, and it was not until he was 23 years old that he was diagnosed. Every two or three days, he needs to inject human chorionic gonadotropin (HCG) to maintain hormone balance in the body. Pan Longfei said that there is a saying in the industry that "rare diseases are rare, but doctors who can see rare diseases are actually even rarer."

Zhang Shuyang, vice president of Peking Union Medical College Hospital, believes that "from caring for frequently-occurring and common diseases to caring for rare and difficult diseases, especially rare diseases with poor prognosis, caring for patients with rare diseases is the embodiment of social development and civilization, and also represents the fairness and justice of medical treatment. The standardization of diagnosis and treatment of rare diseases and the development of orphan drugs will also drive the development of the overall level of medicine. "

In the past year, the country gradually standardized the diagnosis and treatment of rare diseases.

The 2018 edition of the National Essential Medicines Catalogue and the First Batch of Rare Diseases Catalogue jointly formulated by five departments including the National Health and Wellness Commission have been published one after another … Cancer and rare disease patients have ushered in hope.

Recently, from cancer to rare diseases, the state once again introduced a "combination boxing" for the prevention and treatment of major diseases.

-ensuring medication for patients with rare diseases. Following the State Council’s inclusion of supporting "orphan drugs" in the key task of deepening medical reform in the 13th Five-Year Plan in December 2016, on February 11th this year, the Standing Committee of the State Council decided to give value-added tax concessions to drugs with rare diseases. From March 1st, for the first batch of 21 medicines with rare diseases and 4 APIs, VAT will be levied at a reduced rate of 3% for the import link with reference to anticancer drugs, and at home, VAT can be levied at a simple rate of 3%.

On February 15th, official website, National Health Commission issued the Notice of the General Office of the National Health and Wellness Commission on Establishing a National Collaborative Network for Diagnosis and Treatment of Rare Diseases, and selected 324 hospitals with strong diagnosis and treatment capabilities and more cases as collaborative network hospitals to form a collaborative network for diagnosis and treatment of rare diseases.

According to Wang Ping, Director of the Department of Drug Registration of National Medical Products Administration, a special review mechanism has been established for overseas new drugs that are urgently needed in clinic, and the first batch of 48 varieties that are urgently needed in clinic have been selected, including therapeutic drugs for rare diseases and some drugs that are seriously life-threatening. The approval time for therapeutic drugs for rare diseases is concluded within 3 months, and for other urgently needed therapeutic drugs, it is concluded within 6 months. In 2018, 18 new anticancer drugs were approved, an increase of 157% over 2017.

Shorten the "reflex arc" of policy dividends to the grassroots.

Reporters at the grassroots level found that the inability to buy medicine and the high cost of treatment have become a "life and death test" for patients with rare diseases.

The number of patients with some drugs is too small, pharmaceutical companies are unwilling to produce, and patients have no drugs available.

Zhang Shuyang said that among the 121 diseases listed in the first list of rare diseases, there are 54 medicines available for 39 diseases. Among them, 29 drugs listed in China can treat 21 diseases. There are also most rare diseases for which no medicine is available.

Some drugs for rare diseases are expensive, which makes patients daunting. Qin Jiong, director of pediatrics at Peking University People’s Hospital, said that in the United States, the average annual treatment cost for patients with rare diseases is $137,000, a large proportion of which is medicine.

In Wuhan Children’s Hospital, Xiao Yuzhe, who is more than one year old, lies quietly in his mother’s arms, his palm-sized face is covered by a mask, and his small hand is stuck with an indwelling needle. Xiao Yuzhe has been in the hospital for nearly five months.

"Langerhans histiocytosis-his father and I were stunned after hearing the doctor’s diagnosis. Two people sat outside holding their mobile phones and found out that they were crying with their children." Yuzhe’s mother counted with her fingers, and she has spent more than 110,000 yuan since she was admitted to the hospital. "I heard that the follow-up treatment will cost more than 100,000 yuan."

"cladribine, a needle costs more than 7000 yuan, one course of treatment takes 5 sticks, and the follow-up takes 3 or 4 courses. This does not include the cost of other therapeutic drugs. " Li Hui, deputy director of the oncology department of the hospital, said that Yu Zhe’s disease can’t be regarded as leukemia, and it can’t rely on solid tumors. He can’t even enjoy the policy of serious illness relief. This time, the country has published a list of rare diseases, and recently, the tax burden of these rare drugs has been greatly reduced, and the prices should be lowered accordingly, which brings a glimmer of hope to the families of rare patients like Yuzhe’s mother.

Due to the small amount of drugs used for rare diseases and the large investment of enterprises in drug research and development, the drugs for rare diseases produced in China are often scarce or expensive. However, this situation has gradually improved.

For example, Professor Liu Li, Chairman of the Rare Diseases Branch of Guangdong Medical Association and Director of the Department of Genetics and Endocrinology of Guangzhou Women and Children Medical Center, used to want to get drugs for treating rare diseases, but they could not be bought through formal channels. After the patient tried his best to buy the medicine, the hospital dared not give it to the patient. "With the introduction of a series of policies, some therapeutic drugs included in the list of rare diseases have quickly entered the China market through the green channel."

Reporters in Guangdong, Anhui, Hubei and other places learned that 17 kinds of anticancer drugs negotiated by the state have landed, and patients can enjoy medical insurance reimbursement. According to the Anhui Provincial Medical Insurance Bureau, while ensuring the implementation of 17 kinds of anticancer drug policies negotiated by the state, Anhui implemented quantity procurement for another 13 kinds of anticancer drugs at the end of 2018, and the average price of these 13 kinds of drugs dropped by 39.52%. For example, the drug with the biggest drop is gefitinib tablets for the treatment of non-small cell lung cancer, from more than 1,000 yuan per box to more than 400 yuan.

What other "prescriptions" are eagerly awaited by the masses?

At the grassroots level, what are the eager hopes for patients with major diseases to use drugs?

-Strengthen the research and development of new drugs and improve the accessibility of patients’ medication.

Ensuring the supply of orphan drugs is the basis for patients with rare diseases to "save their lives".

Experts from Beijing and Guangzhou believe that it is an indisputable fact that many patients with rare diseases are prone to early disability and young death. It is imperative for hospitals to buy medicines first.

Li Hui and other experts believe that the treatment of rare diseases mainly depends on drugs, and the proportion of drug expenditure in the main medical expenditure of patients with rare diseases often reaches 80% or even higher. The preferential tax on import has brought positive influence to the market of rare disease drugs. If patients with rare diseases can afford high-end drugs, the fundamental solution is to strengthen the production and research of independent drugs.

Yan Shijie, director of gynecology department of the First Affiliated Hospital of Anhui Medical University, believes that "orphan medicine" needs the support of national policies, directional production, tax reduction and exemption, and at the same time, the establishment of national reserve system and alarm mechanism to adjust supply and demand in time.

-Accelerate the improvement of the diagnosis and treatment system for major diseases such as cancer, promote the screening of rare diseases and cancers, and make efforts to reduce the mortality rate.

Early screening and early treatment are the first line of defense-according to clinical statistics, more than 80% of rare diseases are caused by heredity. Li Long, chief physician of Beijing Pediatric Research Institute, believes that the establishment of prenatal screening and physical examination for children is the cheapest and most efficient means to prevent and treat rare diseases. In addition, improving the standardized diagnosis and treatment of rare diseases nationwide, especially strengthening preventive treatment, can prevent them in advance and reduce the disability and death of rare diseases.

Liu Li believes that the establishment of the national rare disease cooperation network is to make the diagnosis and treatment of rare diseases relatively centralized and two-way referral, reduce misdiagnosis and mistreatment, and give patients with rare diseases who have already developed a more suitable diagnosis and treatment plan.

-Optimizing the medical security system. Clinical experts believe that some targeted drugs and immunotherapy are expensive, and it is necessary to establish a multi-level security system and a multi-payment system as soon as possible.

Hao Chunpeng, president of China Medical Insurance Magazine, believes that it is necessary to establish a multi-level medical security system, provide social support through medical assistance and charity, and make various high-level supplements through commercial insurance to ensure people’s different levels of medical needs.

　

　　Yale University scientists revealed the gradual process of quantum transition through a high-speed photography technology. Quantum jump has once again become a buzzword, and it has set off a debate about whether quantum mechanics is random or continuous.

　　As a theory to understand the atomic scale world, quantum mechanics has a core concept that is extremely radical, bold and counterintuitive, and even becomes a buzzword, that is "quantum transition". Most pioneers of quantum mechanics believe that quantum transitions are "random and instantaneous".

　　A new experiment shows that this is not the case. The research was completed by Zlatko Minev, a graduate student of Mike de Vorreith Laboratory of Yale University. He and his colleagues revealed the gradual process of quantum transition through a high-speed photography technique. This achievement was recently published in the journal Nature.

　　The significance of the experiment may be far more than that: researchers use the high-speed detection system to "catch" the quantum transition when it is about to be marked, and then reverse it to restore the system to its initial state.

　　As a result, the inevitable stochastic processes in quantum physics are now proved to be controllable — — Can people really control quantum?

　　Debate on quantum transition

　　Unlike Bohr and Heisenberg’s quantum theory, Schrodinger believes that there is no quantum transition.

　　In the mid-1920s, physicists niels bohr, Werner Heisenberg and colleagues established quantum theory. Bohr first proposed the concept of quantum transition, but it was not observed in the laboratory until the 1980s. This theory is collectively called Copenhagen interpretation.

　　Bohr proposed earlier that the energy levels (i.e. energy states) of electrons in atoms are quantized, that is, electrons can only use certain energy levels, while all intermediate energy levels are forbidden. He assumes that electrons change their energy by absorbing or releasing light quantum particles, that is, photons, and the energy of photons matches the energy gap between the allowed electronic States. This explains why atoms and molecules can absorb or release light with specific wavelengths. For example, many copper-containing salts are blue, while sodium lamps emit yellow light.

　　In a set of mathematical theories developed by Bohr and Heisenberg, which can explain quantum phenomena, Heisenberg listed all the allowed quantum states, suggesting that the transitions between these quantum states are instantaneous and discontinuous. The concept of instantaneous quantum transition has become a basic concept in Copenhagen.

　　However, the Austrian physicist Erwin Schr?dinger, another founder of quantum mechanics, did not agree with this view. In Schrodinger’s theory, he represented quantum particles by wave-like entities of wave functions. Their changes were gentle, and they changed continuously with time, just like gentle waves on the vast sea.

　　Schrodinger believes that things in the real world will not suddenly change greatly without spending a little time, and discontinuous quantum transitions are just an illusion in my mind. In an article entitled "Is there a quantum jump" published in 1952, Schrodinger firmly replied: "No."

　　The focus of the debate between them is not just whether Schrodinger likes sudden changes, but that Bohr and others claim that quantum transitions will occur randomly, but they can’t say why it is that particular time. This is like a result without reason, which is undoubtedly a great challenge to the law of natural causality.

　　In order to explore deeply, people need to observe a single quantum transition. In 1986, three international research teams reported that they observed quantum transitions in a single atom suspended by an electromagnetic field: the atom switches back and forth between a "bright" state and a "dark" state, in which the atom emits a photon, while in a "dark" state it does not emit photons randomly; The atom stays in one of these states for a few tenths of a second to a few seconds, and then jumps again.

　　Since then, people have observed such transitions in different systems, including the transition of photons between different quantum states and the transition of atoms of solid materials between quantized magnetized states. In 2007, a French research team reported that a transition was found, which was in line with what they described as the process of "a single photon from birth, activity to death".

　　In these experiments, the transition really seems to be sudden and random, because even if the quantum system is monitored, no one can tell when the transition will occur, and there is no specific image showing the transition.

　　Capture quantum transition

　　The experiment of Yale University can not only predict the transition, but also reverse it.

　　How exactly did Yale University do this experiment?

　　Generally speaking, they use a special method to indirectly monitor superconducting artificial atoms, that is, three microwave generators are used to irradiate atoms enclosed in an aluminum three-dimensional cavity. This dual indirect monitoring method developed for superconducting circuits enables researchers to observe atoms with unprecedented efficiency. They found that every time a quantum jump occurs, a tiny photon disappearance phenomenon will occur, which can be regarded as an early warning signal.

　　Minev, the first author of the paper, said: "Using this phenomenon, we can not only predict the transition, but even reverse the transition."

　　The researchers said that although quantum transitions are discrete and random in the long run, preventing quantum transitions means that the evolution of quantum States is deterministic to some extent, rather than completely random; Transitions always occur from their random starting points in the same and predictable way.

　　The quantum system used by researchers is much larger than atoms, and it is composed of cables made of superconducting materials, sometimes called "artificial atoms" because they have discrete quantum energy states, similar to the electronic states in real atoms. Transitions between energy states can be induced by absorbing or releasing a photon, just like electronic transitions in atoms.

　　Some scientists believe that this research may also be applied to quantum computing error correction. However, the real value of the experimental results lies not in any practical application, but in our understanding of the quantum mechanical system.

　　How can Schrodinger’s cat be saved

　　Through correct monitoring, we can observe an early warning signal and take action.

　　Schrodinger’s cat paradox explains the concept of "superposition" in quantum physics (that is, two opposite states can coexist) and unpredictability: a cat is placed in a sealed box with a radioactive source and a poison in it. If one atom of radioactive material decays, it will release poison. According to the superposition theory of quantum physics, before someone opened the box, the cat in it was both alive and dead, that is, in the superposition state of two States. Once the box is opened and the cat’s life and death are observed, its quantum state will change immediately and become one of "dead" or "alive".

　　Yale University’s research shows that an early warning signal can be observed during quantum transition, which makes Schrodinger’s cat saved.

　　Because the decay of nuclear is a random event, physicists only know the probability of its decay, and can’t know when it decays. If the nucleus decays, releasing alpha particles, triggering the electronic switch, the hammer falls, smashing the poison bottle and releasing cyanide gas, the cat will be poisoned.

　　If physicists don’t open the lid of the secret room, it is uncertain whether the cat is dead or alive, and it is in a superposition state of both death and life. Only when the lid is lifted can we know for sure whether the cat is dead or alive. In this way, the microscopic uncertainty principle has become a macroscopic uncertainty principle.

　　Yale University researchers use an indirect observation method in the experiment, which is also a "weak measurement" method widely used in the field of quantum information, and will not disturb the observed object. Researchers believe that the transition of a particle is neither as sudden nor as random as previously thought, and the evolution of quantum state is deterministic rather than random to some extent. Theoretically, through correct monitoring, we can definitely find the warning of the coming disaster, and take action before the disaster, and remove the poison bottle at the moment when the nuclear decay is predicted, so Schrodinger’s cat was saved. Minev said: "The quantum transition of atoms is somewhat similar to volcanic eruption. In the long run, they are completely unpredictable. Nevertheless, through correct monitoring, we can accurately get the early warning of the impending disaster and take action before it happens. "

　　The foundation of quantum mechanics has not been affected.

　　The paper clearly shows that the experimental results are in good agreement with the theory of quantum mechanics.

　　According to von Neumann’s summary, quantum mechanics has two basic processes, one is deterministic evolution according to Schrodinger equation, and the other is random collapse of quantum superposition state caused by measurement. Schrodinger equation is the core equation of quantum mechanics, which is deterministic and has nothing to do with randomness. Then the randomness of quantum mechanics only comes from measurement.

　　This randomness of measurement is what Einstein can’t understand. He used the metaphor that "God can’t roll the dice" to oppose randomness of measurement. However, countless experiments have confirmed that the result of directly measuring a quantum superposition state is random. In order to solve this problem, many interpretations of quantum mechanics have been born, among which three mainstream interpretations are Copenhagen interpretation, multi-world interpretation and consistent historical interpretation.

　　According to Copenhagen interpretation, measurement will lead to the collapse of quantum state, that is, quantum state will be destroyed instantly and fall to an eigenstate randomly; According to the multi-world interpretation, every measurement is a division of the world, and the results of all eigenstates exist, but they are completely independent of each other and do not interfere with each other. We are just randomly in a certain world; Consistent historical interpretation introduces quantum decoherence process, which solves the problem from superposition state to classical probability distribution. However, in choosing which classical probability, it still goes back to the debate between Copenhagen interpretation and multi-world interpretation.

　　Professor Li Chuanfeng from the Key Laboratory of Quantum Information of China Academy of Sciences told the Science and Technology Daily reporter that these interpretations predicted the same physical results, and they could not be falsified, so the physical meanings were equivalent. Therefore, the academic circles mainly adopted Copenhagen interpretation, that is, the word collapse represented the randomness of measuring quantum states.

　　"The experiment of Yale scholars has not affected the foundation of quantum mechanics, that is, the inherent uncertainty of quantum mechanics." Li Chuanfeng said that the quantum transition is certain for the wave function itself, just like a dice, and it is certain that it can’t roll 7 points. The wave function can calculate how the particle probability cloud in quantum state evolves, but once the measurement problem is involved, the Schrodinger equation cannot be solved. The only way is to calculate the probability of particles, such as position probability, momentum probability and so on.

　　"In fact, as early as 1986, a research team confirmed through experiments that quantum transitions take time. Yale University found that quantum transitions not only take time, but also send out an early warning signal before each transition. " Li Chuanfeng said that this is like saying that someone wants to jump long, but it is impossible to predict when he will take off, but before jumping forward, his body will lean forward and raise his arm to swing back and forth, and there is a definite causal relationship between these two things. Just hit him as soon as he raises his arm, and he won’t jump. However, when this early warning signal appears is still probabilistic. As for the "overturning quantum mechanics and overturning the uncertainty principle of quantum mechanics" circulating on the Internet, it is not involved in the experiment at all, and it is clearly stated in the paper that the experimental results are in good agreement with the theory of quantum mechanics.

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　 　 　 　 On the social networks where Zhihu, Douban and other young artists gather, there has never been a lack of such topics as "XX absolutely beautiful unpopular songs" and "Recommend some popular music that is nice but not popular". There is no distinction between the public and the minority in the genre of music. The so-called minority or unpopular music is mostly defined according to the amount of play or the audience.

　 　 　 　　Van adib, CEO of eCast, discovered the famous "98 Rule" in his research on digital music, that is, the audience has unlimited demand for 98% of non-popular music, and the market for non-popular music collections is enormous and boundless.

　 　 　 　　On the one hand, there is a strong user demand, and on the other hand, there is a huge market prospect. How to recommend these 98% unpopular songs to the audience has been tried by music service providers all over the world, as has the domestic online music platform, and Netease Cloud Music, which stands out by virtue of the unique positioning of the music community, is one of the best. Compared with the average utilization rate of music libraries below 20% in the industry, Netease Cloud Music has reached 80% of "going against the sky". In addition to the ingenuity of products, Netease Cloud Music has mainly done two things right.

1. Reconstruct the music recommendation method.

　 　 　 　　Netease Cloud Music was launched in April 2013. At that time, most of the music software on the market was "music library+player", which played the role of listening to songs. It is not difficult to understand the phenomenon mentioned at the beginning of this article. Users can’t find their favorite music in the music player, and interest-oriented online communities have become a natural medium for discovering and sharing music.

　 　 　 　　The appearance of Netease Cloud Music has changed the traditional music recommendation method, mainly in two aspects, one is song list, and the other is personalized recommendation.

　 　 　 　　Let’s start with the song list, which is similar to the song sharing article on Douban, but it is transferred from a third-party social platform to a music APP, which is also in line with the positioning of Netease Cloud Music Music Community. The song list has realized two direct functions. In the past, the chaotic song collection was solved after joining the song list. In the past, users had a strong dependence on various lists to find songs, which actually accelerated the difference between popular and non-popular. Songs appearing on the list will be heard by more people, while music outside the list may become a long tail. On Netease Cloud Music, song list has replaced the list as a popular listening behavior.

　 　 　 　　Up to now, the number of high-quality song lists created by users on Netease Cloud Music has exceeded 200 million, with an average of 420,000 song lists created every day. This figure far exceeds the posts recommended by music on social platforms. Through the song list, users can find the music they listen to at work, the lullaby they listen to when they are insomnia, the unpopular music they can’t miss, and even the background music of PPT. Not only has it solved the pain points of users, but for Netease Cloud Music itself, the song list has become a "trump card" to maintain the stickiness of users.

　 　 　 　　Personalized recommendation is another initiative to solve the problem that users find good music, so Netease Cloud Music is also called a music player that "knows you better than your mother".

　 　 　 　　The great god in Zhihu has a professional explanation for the recommendation mechanism of Netease Cloud Music, which is mainly divided into two parts in algorithm, the recommendation of similar people and the recommendation of similar songs. As the name implies, similar songs mainly Tag songs in the music library, and push music with similar tags or the same tags according to users’ listening habits. The recommendation of similar people refers to modeling according to users’ listening habits, and screening out people with similar tastes. For example, A and B belong to the same kind of people, and the songs that A likes are probably the ones that B is willing to listen to.

　 　 　 　　Through song list and personalized recommendation, Netease Cloud Music has established a recommendation mechanism of "algorithm+labor +UGC", which not only satisfies the interest of users, but also ensures the quality of products.

　 　 　 　　There is a "story from Netease cloud music to the real world" circulating on the Internet. GalenCrew is a relatively small singer in both China and the United States, but his single Sleepyhead has tens of thousands of comments on Netease cloud music. Finally, Galen began to tour in China, and the venue was full.

2. Break the barriers of music sharing

　 　 　 　　Music sharing in the traditional sense is mostly word of mouth or shared on social networking platforms. After all, it is still the active sharing of users. Especially for minority music, many listeners have a mentality of "like it but don’t want it to be popular", and it is difficult for traditional sharing methods to break this boundary.

　 　 　 　　In essence, the song list and personalized recommendation on Netease Cloud Music also belong to the category of sharing. The song list was created spontaneously by users and found and collected by "music friends" with similar interests, among which there were many song lists with hundreds of thousands or even millions of listeners. According to the personalized recommendation of similar people, the sharing process was imperceptibly completed.

　 　 　 　　However, what Netease Cloud Music enjoys in sharing is the positioning and comment mechanism of the music community. The former meets the needs of users to share good music, so that good music can be shared with like-minded people, which is in line with the behavior habits of minority music lovers. Many listeners of minority music have their own circles. They recognize each other’s identity and values and enjoy the sense of security that this group gives them. And this kind of people in the hope of independence and eager to communicate, we strive to expand the small circle, while trying to control the small circle in the illusion of independence. Compared with popular social channels, Netease Cloud Music’s vertical socialization is just what it wants.

　 　 　 　　But music itself is also a commodity, and it is bound to be tagged. When we listen to songs, the background data of online music is constantly tagging us. The so-called niche only exists in data algorithms. This kind of label is a good thing for the promotion of minority music. Compared with the promotion for individuals, the label-oriented group has more advantages in both accuracy and cost. How to recommend minority music to more people’s ears according to this feature? Netease Cloud Music chose the comment mechanism.

　 　 　 　　The Indonesian song "Bila" has 25,000 comments on Netease Cloud Music, and the most praised comments are 46,000.

　 　 　 　　Yes, it’s a comment, not a grade. According to the rules of scoring, users score their favorite or disliked music, and then find out similar user groups on the difference of scoring. However, if there is a score, there will be a brush score, which will lead to irrational behavior of the user group and even cause the loss of users in a large area. In addition, letting users rate songs that have been listened to for a few minutes increases the cognitive cost of users, and it is also a kind of harm to music itself. Music has no advantages or disadvantages, only likes and dislikes.

　 　 　 　　Netease Cloud Music’s comment mechanism has achieved results. At present, it has generated 400 million comments, and users have generated 640,000 music comments every day. More than 50% of users have developed the habit of commenting while listening to songs. Compared with the digital rating, this kind of comment entrusts users with more emotional factors, such as excellent comments will be praised at the top. Moreover, music criticism itself is a kind of sharing, and it is a way for users to express their love for works. Even some relatively unpopular music still gets tens of thousands of comments.

　 　 　 　　Almost all fields are looking for explosions, such as e-commerce, IP, and even music. But distributing pop music to more people is an ability to bring more fans to minority music or unpopular songs. This is feelings.

Source: China Network

Li Xin is very proud that it can help more young people returning home to start businesses. (Photo by wanglili)

　　Cctv news(Reporter wanglili): Yinchanggou Village, Foping County, Shaanxi Province is a mountain except a mountain.

　　In 2006, in order to make a living, only Jiang Dong, a villager with junior high school education, walked out of the mountain in Yinchanggou Village. At the age of 20, he felt that only by going out could he see hope and get rid of poverty.

　　In 2013, Jiang Dong, who had been working outside for seven years, was getting married and returned to his hometown with his wife Li Xin, who also worked in Wuxi Hotel.

　　After the banquet, looking at the elderly parents and thinking about the upcoming baby, after repeated discussions, the two decided not to go out and stayed in their hometown to find a way to start a business.

　　At this time, my hometown is still a high mountain, and the monotonous and repetitive scene makes Jiang Dong feel very confused. "When I was in Wuxi, the two of us worked in hotel management, and we had experience in this field. We wanted to continue to engage in our old job, but our hometown simply did not have these resources and needs."

　　Just when the couple were at a loss, they accidentally walked into the furniture city, and a palm mat with a selling price of nearly 10,000 yuan suddenly aroused Jiang Dong’s interest. "There are mountain palms all over the mountains in my hometown. Why can’t we make our own palm mats?"

　　As the saying goes, relying on mountains to eat mountains, relying on water to draft. Yinchanggou village has more than 6500 mu of forest land, which is very rich in forest land resources. Wild palm is a common forest in Qinling Mountain, which has the characteristics of moisture resistance, corrosion resistance and no insects. However, the mountain palm resources can not be further processed, which is also a problem that has been puzzling the local income increase. In this way, the green, environmentally-friendly and promising palm mat project was supported by the local government. At the end of 2014, Jiang Dong and his wife Li Xin, after systematically learning related technologies, took more than 200,000 yuan accumulated from working and set up a mountain palm professional cooperative in their farmyard.

　　After several years of hard work by the couple, the humble palm forest on the hillside has become a beacon. “6— 16 cm palm mat, the current market price is 480 yuan — From 3,000 yuan, we can sell more than 20 palm mats a day, with a turnover of 30,000 yuan. " Li Xin said.

　　Like many mountain villages, the villagers in Yinchanggou Village are mostly elderly people, and the loss of young and middle-aged people is serious. Many elderly people and women who stay at home have to take care of their children and fields, so they can’t go to work in the factory. According to their living characteristics, Li Xin distributed some of the knitting, sewing and packaging of brown mats so that they could finish them at home.

　　"In this way, they can not only take care of their families, but also have extra income to subsidize their families." Li Xin said that at present, the company has changed from the original small family workshop to industrial production, with an annual output value of 27 million yuan. In addition, by encouraging villagers to work in factories, share shares and share dividends, and collecting and sorting brown hair, transportation and sales, more than 100 people were recruited to work and increase their income, which was recognized by Foping County as a "demonstration base for returning migrant workers’ entrepreneurship".

　　If education is a long-term way to change the face of poverty, Mao Youbin, secretary of the branch of Yinchanggou Village, thinks that the rural economy can be better developed by giving the people the job opportunity to earn money and support their families at home, and by increasing their income through employment nearby.

　　"It is necessary to introduce enterprises, stay and serve well." In the interview, this is what the reporter heard the most from the local cadres. From individuals to groups, from rural areas to cities, from leaving to feeding back, with more and more policy support, I believe that more and more people who leave home are preparing for a better return home.

　　Human biological clock (circadian rhythm) is an adaptive cycle produced by human beings in order to conform to the periodic laws of nature. Recently, studies from the United States and Britain show that eating by the order can prevent many diseases.

　　Dr. David Becktod, a researcher at the University of Manchester in the United Kingdom, and his research team studied the specific effects of biological clocks on metabolism and digestion in mice. It was found that eating at the wrong time (such as late at night) would lead to the disorder of biological clock, and then trigger the release of insulin, which would stimulate the protein in the body to become more active when it was unnecessary, which would increase the risk of diabetes, obesity, metabolic disorder and heart disease.

　　Dr. Ben J. Greenwell, a professor of genetics at Texas A&M University in the United States, fed a group of mice rhythmically, while the other group ate at will. Five weeks later, the researchers examined the gene expression in the liver of mice at different times of the day. Comparative analysis showed that 70% of mice who ate irregularly lost rhythm in liver transcription cycle compared with mice who ate by points. Dr. Greenwell said that the rhythmic gene expression in the human body can ensure the running cycle of physiological behaviors such as metabolism. When the circadian rhythm is normal and the eating pattern is regular, the expression of most genes in the liver will keep rhythm to prevent liver diseases. Michael krupa, an American preventive medicine expert, said that "eating with the sun" (eating according to the biological clock) can improve the work efficiency of the body.

　　Cctv newsAccording to the website of the Central Meteorological Observatory, it is estimated that from 08: 00 on the 9th to 08: 00 on the 11th, the lowest or average temperature in the eastern part of northwest China, most of Inner Mongolia, most of North China, most of Northeast China, Huanghuai, western and northern Jianghan, northwestern Jianghuai and western Jiangnan will drop by 6 ~ 8℃, and the Central Meteorological Observatory will continue to issue a blue warning of cold wave at 6: 00 on November 9th. Affected by cold air, sleet or snow will appear in central and eastern Inner Mongolia and most parts of Northeast China.

　　Cooling occurred in the eastern part of Northeast China and northern Xinjiang.

　　Yesterday, snowfall, rain or sleet was 1 ~ 7 mm in parts of northeastern Xinjiang, northeastern Jilin, southern Qinghai and northeastern Tibet; Moderate rain occurred in parts of southeastern Guangxi and eastern Hainan, and the local area was heavy rain.

　　At 5 o’clock today, compared with 5 o’clock yesterday, some areas in the eastern part of Northeast China and northern Xinjiang have cooled by 6 ~ 8 C, and the local temperature has dropped by 10 ~ 12 C.

　　Cold air affects the heavy snowfall in Inner Mongolia, Heilongjiang and other places in the central and eastern regions.

　　It is estimated that from 08: 00 on the 9th to 08: 00 on the 11th, the minimum or average temperature in the eastern part of northwest China, most of Inner Mongolia, North China, most of Northeast China, Huanghuai, western and northern Jianghan, northwestern Jianghuai and western Jiangnan will drop by 6 ~ 8℃, among which, the temperature drop in some areas of northwestern Shaanxi, western and northern Shanxi, central Inner Mongolia, eastern Jilin and northeastern Liaoning can reach 10 ~ 12℃. In the early morning of the 11th, the minimum temperature line of 0℃ will be located in southern Gansu, northern Guanzhong Plain in Shaanxi, central Hebei and southern Liaodong Peninsula. The Central Meteorological Observatory continued to issue a cold wave blue warning at 6 o’clock on November 9.

　　Affected by cold air, sleet or snow will appear in the central and eastern Inner Mongolia and most of the northeastern regions, with moderate to heavy snow and local snowstorms in parts of northeastern Inner Mongolia, northeastern Heilongjiang and eastern mountainous areas of Jilin.

　　Affected by cold air, during the day on the 10th, there were 7-8 northwest winds with gusts of 9-10 in Bohai Sea, Bohai Strait, northern and central Yellow Sea. In addition, from the night of the 9th to the night of the 11th, affected by the tropical system, there will be 7-8 winds in the central and southeastern parts of the South China Sea, with winds of 9-10 and gusts of 11-12 in some areas. The Central Meteorological Observatory issued a gale forecast at sea at 06: 00 on the 9th.

　　Before the influence of cold air, on the 9 th, there were intermittent mild to moderate haze in central and southern North China, western Huanghuai, Shaanxi Guanzhong, western Jianghuai, Jianghan, central and western Jiangnan and southern Sichuan Basin. From the night of the 9th, due to the influence of cold air, the haze weather in the above areas will weaken and dissipate from west to east.

　　Future specific forecast

　　From 08: 00 on the 9 th to 08: 00 on the 10 th, there were small to medium snow or sleet in central and eastern Inner Mongolia, north-central Northeast China, south-central and eastern Qinghai, northern Tibet and central Gansu, among which there were heavy snow and local snowstorms in parts of northern Heilongjiang and northeastern Inner Mongolia. There are small to moderate rains and local heavy rains in the southeastern part of Northwest China, the eastern part of Southwest China, the northern part of Huanghuai, the southern and eastern parts of North China, the southern part of Northeast China, the central and western parts of Jiangnan, and the northwestern part of Guangxi. There are 4-6 northerly winds in central and eastern Inner Mongolia, North China, Northeast China and Huanghuai. There are 7 ~ 8 northeast winds and 9 gusts in the Taiwan Province Strait.

　　From 08: 00 on the 10 th to 08: 00 on the 11 th, there were heavy snow and local snowstorms in parts of the western Tianshan Mountains in Xinjiang and Altay Mountains, northeastern Heilongjiang, and eastern Jilin Mountains; There are small to moderate rains or showers in the southeastern part of Northwest China, the eastern part of Southwest China, the western part of Huanghuai, the western part of Jianghan, most of the south of the Yangtze River, southern Yunnan, the eastern part of Hainan Island and Taiwan Province. There are 4 ~ 6 winds in central and eastern Inner Mongolia, Northeast China and North China. There are 7-8 winds and 9 gusts in the Bohai Sea, the Bohai Strait and the northern and central parts of the Yellow Sea. There are 7-8 winds and 9 gusts in the north sea area south of the central and southeast of the South China Sea. The winds in some sea areas can reach 9 and the gusts are 10-11.

　　From 08: 00 on the 11 th to 08: 00 on the 12 th, there were small to medium snow or sleet in parts of northern Xinjiang and northern Gansu; There are small to moderate rains or showers in the southeastern part of Northwest China, the eastern part of Southwest China, Jianghan, the northern and western parts of Jiangnan, southern Yunnan, western Guangxi, southern coastal areas of Guangdong, Hainan Island and eastern Taiwan Province. There will be 7-8 winds and 9 gusts in the central and western parts of the South China Sea, and the winds in some areas can reach 9-10 and 11-12 gusts.

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　　(Health Times reporter Wei Chuannan Health Times special correspondent in Beijing Chest Hospital Li Yun)In the past 20 years, more than 8,000 patients have been consulted after operation, and various premonitions before the onset of myocardial infarction have been found.

　　Professor Zhang Jian, director of the Heart Center of Beijing Chest Hospital, has always maintained a habit in his clinical work for more than 20 years. After each patient has finished the operation, he should ask them what improvements their bodies have made after the operation, what symptoms appear and what symptoms disappear. This question is more than 8,000 cases.

　　Among these more than 8,000 patients, he accidentally discovered many phenomena that were not mentioned in textbooks. An old gentleman, who had never opened his eyes for eight years, suddenly opened his eyes after heart surgery. A lady suddenly lost her hearing. After the stent operation, her hearing magically recovered. A middle-aged man was dizzy for more than two years. I don’t know how many times I ran to the neurology department, but I couldn’t find anything wrong. Later, after an operation for heart discomfort, my head suddenly became dizzy … …

　　"When a heart problem occurs, it is generally believed that there is chest pain. But in fact, heart problems can be manifested in the whole body, dizziness, headache, hearing loss, tinnitus, heavy eyelids, blurred vision, soreness and numbness in the left lower limb, and a feeling of chest banding. Symptoms may occur from head to toe, making heart problems hidden and complicated. It is difficult to diagnose, and patients are in danger and cannot be diagnosed, thus causing accidents. " Director Zhang Jian reminded that when there is a problem with the heart, the symptoms are sometimes unexpected.

　　Accidental rehabilitation

　　Heart surgery solved the eye problem.

　　There was an old man who found Director Zhang Jian because of angina symptoms. After doing cardiac angiography for the old man, he was diagnosed with high stenosis of the anterior descending branch and needed stent surgery.

　　Before the operation, the old man’s son said that he hadn’t opened his eyes for eight years. Anyway, he needed to be hospitalized for this operation. Could you please ask an ophthalmologist for a consultation, first cure his eyes and then treat his heart?

　　After seeing the old man’s condition, the ophthalmologist diagnosed trichiasis. Simply put, eyelashes grow into the eyes, which irritates the cornea and makes the eyes hard to open. He said, "This treatment is simple. Let the old man go to the eye clinic for a minor operation and pull it out."

　　As a result, the old man was pushed out again after ten minutes in the clinic. The doctor said that I had to open his eyelids and pull out his eyelashes with tweezers to operate on him, but I couldn’t open the old man’s eyelids, and the strength was too great. I closed them immediately after opening them.

　　His son said, in this case, let’s treat the heart first. At ten o’clock that day, Director Zhang Jian finished the heart stent surgery for the old man. At twelve o’clock, Director Zhang Jian went to the ward to visit him. When he entered the door, he was very surprised because the old man’s eyes were open!

　　"This surprised me, because we didn’t do any treatment for the old man’s eyes during the operation. Therefore, I concluded that his eye problem was caused by heart ischemia, the blood supply to the heart was restored, the blood supply to his eye nerve was normal, and his eyelids were opened. " Director Zhang Jian introduced that this is the first patient he encountered with eye symptoms caused by cardiac ischemia.

　　A few years later, Director Zhang Jian met two very similar patients in the outpatient clinic. The first sentence of a woman who came to see a heart attack was, "Director Zhang, my eyelids are so heavy these two days that I can’t open them if I don’t want to. I feel like my eyelids weigh a few thousand pounds, and then I feel bored and weak."

　　As soon as Director Zhang Jian heard this, he thought of the old man before, so he gave her a piece of nitroglycerin in the clinic. After a while, the lady said, "Oh, my eyelid used to weigh 1,000 kilograms. Now it’s very easy. I can lift my eyelid!" .

　　Among Zhang Jian’s patients, not only the eye problems recovered unexpectedly after heart surgery, but also the ear problems of the patients, which were solved unexpectedly after heart surgery.

　　Ms. Su from Shandong once received a business trip and wanted to go to Hangzhou. Before boarding the plane, her hearing was normal, but after getting off the plane, her ears suddenly could not hear clearly.

　　At that time, she was examined in the otolaryngology department of a hospital in Hangzhou and was diagnosed with sudden deafness. After returning home from a business trip, Ms. Su went to the otolaryngology department of a hospital in Shandong. The doctor said that her condition was not sudden deafness, but hearing loss, and introduced an expert who was good at microvascular decompression.

　　When Ms. Su heard about it, she immediately contacted the expert. The expert first operated on Ms. Su’s left ear. As a result, after the operation, Ms. Su’s left ear was not only deaf, but also completely deaf. Now she didn’t dare to continue to operate on her right ear. She was afraid that both ears would be completely deaf, so she had to go home.

　　After a while, Ms. Su found something wrong with her cardiovascular system in a physical examination. Under the introduction of others, she found Director Zhang Jian, who performed heart stent surgery for her.

　　On the second day after the operation, Ms. Su was surprised to find that her hearing recovered. It turned out that her sudden hearing loss in both ears was a signal from heart ischemia!

　　Director Zhang Jian explained that the nerve distribution of the eyes, ears and cardiovascular system has certain correlation. When the cardiovascular system has problems due to atherosclerosis, it may affect the blood supply of the nerves in the eyes and ears, which may cause heavy eyelids and ischemic deafness. Therefore, the early signs of heart problems may be manifested as symptoms in these two places, which need attention.

　　Run the wrong department

　　Visiting respiratory experts turned out to be a heart disease.

　　From Hong Kong to Shenzhen, and then to Beijing, Mr. Li couldn’t breathe because of his chest discomfort. He went to several hospitals and was diagnosed with health problems, asthma and pneumonia respectively. It was not until he met Director Zhang Jian in Beijing Chest Hospital that he realized that his heart was out of order.

　　This gentleman was met by Director Zhang Jian during a consultation with his colleagues. At that time, director Zhang Jian was originally arranged to see another old man with heart discomfort. Mr. Li, who is in his 40 s, asked the director of respiratory department to look at the lung film for him to diagnose his illness.

　　When the respiratory expert saw that Director Zhang Jian was there, he said, "Heart and lung are not separated. Let’s take a look at this film." Director Zhang Jian said: "I don’t understand lung disease, so I won’t watch the film. I’ll ask about it."

　　When chatting with patients, Director Zhang Jian learned that he suddenly felt uncomfortable in his chest a few months ago. "Do you know the feeling of being entangled in transparent tape? My chest is now like being wrapped in a circle of scotch tape. It is very uncomfortable and I can’t breathe. " The patient said that he has a habit of getting up at six o’clock every morning and running for half an hour. This uncomfortable feeling will be fine as soon as he runs, but after he comes back from running for half an hour, he feels that his chest is turned up by scotch tape.

　　Mr. Li’s main career is in Hong Kong, so he went to see a doctor in Hong Kong first. The doctor gave him the conclusion that his health was fine. He didn’t believe it. How could he be fine if he was out of breath? He went to Shenzhen again, and then to Beijing. The doctors basically gave two opinions. One was asthma, but after Mr. Li was treated according to the asthma plan, his breath became more serious. Another opinion was pneumonia. He heard that Beijing Chest Hospital was better and came.

　　When Director Zhang Jian heard this, he thought that Mr. Li’s problem might not be his lungs, but his heart. He explained: "This symptom can’t be pneumonia, because inflammation is a substance, and it is impossible to walk for a while. Like this patient, it is not uncomfortable to run, but uncomfortable to run, so it will not be inflammation."

　　So, he asked the patient to go to the pharmacy to get nitroglycerin, and did a nitroglycerin test for him in the clinic. It took only four minutes, and he stood up from the sofa and said, "Director Zhang, the tape wrapped around my chest has disappeared!"

　　Later, after examination and diagnosis, Mr. Li was diagnosed with myocardial ischemia. After the operation, the feeling that his chest was twisted with tape never appeared again.

　　Regret death

　　Ignoring the heart distress signal from the leg

　　Heart problems will also be manifested as leg symptoms first, which was discovered by accident by Director Zhang Jian after an operation.

　　A friend called Director Zhang Jian one day and said that a relative in his hometown had a narrow anterior descending branch of his heart and wanted to see him for surgery. Director Zhang Jian agreed. After the cardiac stent surgery for patients, Director Zhang Jian routinely went to the ward to ask the patients what symptoms had improved. "This is my habit. I have to ask in detail about each of my more than 8,000 surgical patients. What improvements have been made after surgery, what symptoms have appeared, which symptoms have disappeared, and the summary of many symptoms can only be found after I continue to ask after surgery." Director Zhang Jian explained.

　　However, the patient replied, "There is no place to feel the symptoms relieved." Director Zhang Jian asked, "If you think about it again, isn’t there anything better in your body than before?" The patient thought about it, and said, "If you ask me, I think the problem on my leg has gone to 80%. In the past, my leg was uncomfortable and sore. I went to see a doctor everywhere in my hometown, went to the orthopedics, did CT, did MRI, looked at the lumbar spine, and checked the blood vessels, nerves, muscles, etc., but I didn’t find any problems. Later, I went to see a Chinese doctor, and I tried massage, acupuncture and cupping, but it didn’t improve.

　　Director Zhang Jian was deeply impressed by the patient’s answer, because he had never met a similar patient before, so in a later community clinic, he told the residents the patient’s story to remind everyone to pay attention to the heart distress signal from his leg.

　　After listening to Director Zhang Jian’s talk, an old lady made a special trip to find Director Zhang Jian after the lecture. She said, "You are right. My wife died like this a few years ago. He was fine when he got up that morning. In the morning, he suddenly said that his left leg was uncomfortable, painful, numb and bloated. Because of the severe pain, he and I went to the hospital to see a doctor with an orthopedic number and opened a lot of examinations. As a result, in the evening, people died. I quickly did an electrocardiogram and found out that it was a heart problem, but it was too late, and my wife died that night. " The old man regretted that if he had learned this knowledge before and went to the cardiology department in time that day, the outcome might be different.

　　"Of course, not all pain in the left leg is angina pectoris." Director Zhang Jian suggested that some leg pains can rule out heart problems.

　　Before that, he also treated a 76-year-old gentleman, saying that his leg hurt badly, especially his left leg, and he could hardly touch the ground, let alone exert himself. When brushing his teeth, he can only stand on his right leg, and sometimes he can’t persist in urinating, but his right leg is fine. The old man said that he had an angiogram six months ago, and there was about 70% stenosis, but he didn’t do it at that time. Recently, however, I have always been flustered, sweating, and blurred vision. He suspected that he was angina pectoris and came to the clinic.

　　Director Zhang Jian asked the old man to lie down and check. First, he lifted his right leg to 70 degrees, so Director Zhang Jian lifted his left leg again. Before it reached 30 degrees, the old man twisted with pain and could not raise it any more. The old man was given nitroglycerin, and his leg pain did not relieve. After reading his previous examination results, Director Zhang Jian basically determined that the pain in the old man’s left leg was caused by lumbar disc herniation and nerve compression. Lying flat and lifting your legs should not exceed 30 degrees, which is a typical symptom. Taking nitroglycerin has not alleviated it, and it can basically be ruled out that it is a heart problem.

　　Although the old man’s leg pain has nothing to do with his heart, Director Zhang Jian judged that the old man’s heart still has some problems, because the occasional blurred vision is a manifestation of insufficient blood supply to the brain. The stenosis of the anterior descending branch leads to a large area of heart ischemia, which will lead to a drop in blood pressure and blurred vision. The duration of his blurred vision is consistent with the characteristics of myocardial ischemia. In addition, the old man’s heart rate is too fast to reach more than 180, which will also lead to cerebral ischemia. Because of the complicated reasons for the high heart rate, Director Zhang Jian further made relevant examinations for him to clarify his condition.

　　Director Zhang Jian explained that the pain in the left leg did appear in some patients with myocardial ischemia. After improving the blood supply to the heart through treatment, the pain in the left leg disappeared. For this patient, although it was ruled out that leg pain was caused by myocardial ischemia, other heart problems were found in time.

　　Periumbilical pain

　　High-risk groups should suspect angina pectoris.

　　Director Zhang Jian reminded that the heart is like the main valve of human blood vessels. When there is a problem with this valve, the blood supply of many branches may be affected, so it is the first to send an alarm signal in other places. If you receive these signals and see a doctor in other departments, you can’t find the obvious reason. Don’t be careless. You must go to the cardiology department for examination and check the heart problems.

　　A Shandong patient, because of the pain around the umbilicus, looked for an expert in the digestive system to see a doctor. He first checked the digestive system in a local hospital and found no problems. I went to the provincial hospital for gastroscopy and enteroscopy, even capsule gastroscopy, and found nothing unusual. Later, he turned around and found Director Zhang Jian.

　　"When I saw this patient, I thought of a patient with periumbilical pain who had been rescued before. The patient was in a hurry. He began to have a stomachache after going out for a walk in the morning. At first, I thought it was a stomachache. Later, the pain around the navel became more and more intense, and I called 120 to the emergency department of a nearby hospital. In the emergency department, the patient was in his 50 s, with stomachache, cold weather and low body temperature, and he was highly suspected of angina pectoris. He was soon given an electrocardiogram, which really showed acute inferior myocardial infarction. Based on the principle of urgency, the ambulance sent him to me. Do coronary angiography, and sure enough, the right crown is 100% occluded! After the thrombus aspiration, the patient’s periumbilical pain disappeared on the operating table. "

　　Director Zhang Jian said that because of his previous experience, as soon as the Shandong patient arrived here, he first considered that he might also have angina pectoris. Later, angiography showed that 99% of his circumflex branch was occluded. After revascularization, his periumbilical pain quickly disappeared.

　　Director Zhang Jian explained that the recovery of myocardial blood supply and the disappearance of abdominal pain are synchronized in time, which means that some patients’ angina pectoris is manifested by periumbilical pain. Therefore, he reminded that periumbilical pain should be highly suspected of angina pectoris for high-risk groups with myocardial infarction!

　　The data show that the number of sudden cardiac death in China exceeds 500,000 every year, and 95% of sudden cardiac death occurs outside the hospital, and 80% of them occur at home. Therefore, early detection of symptoms of myocardial ischemia is very important for saving lives in time. Director Zhang Jian reminded us that we should open our minds to the understanding of myocardial infarction and angina pectoris, and not just focus on distressed chest tightness. If you are a high-risk group and have the above strange symptoms, you must have more strings in your mind. Is it a heart problem? Perhaps, the problem of a long struggle will be solved.

Reporter’s notes

　　Because of frequent communication with patients, Director Zhang Jian not only found strange signs of myocardial infarction, but also knew what patients needed and what patients could understand. It is also in this exchange that Director Zhang Jian found that everyone’s knowledge of heart health is far from enough. Therefore, he basically holds a lecture in the outpatient hall of the Heart Center of Beijing Chest Hospital every week, with the theme of popularizing heart health knowledge. "I hope that through the lecture, everyone will have a string in their minds. When there are some symptoms that seem to have nothing to do with the heart, we should think about whether there is something wrong with the heart, even if we go to the community to do an electrocardiogram nearby, sometimes we can avoid some accidents."

　　Director Zhang Jian’s lecture site is often packed. The existing chairs in the outpatient hall are all full, and many people are still standing in the back row. After more than an hour of lectures, few people leave halfway. Some old people even put on reading glasses and take out paper and pens to record carefully. "Director Zhang is the doctor who knows the most about health knowledge." An audience member said that listening to Director Zhang Jian’s lecture on health science is not boring, just like listening to a story. After listening to the story, the heart knowledge is also remembered.

With the development of intelligent driving technology, more and more cars are equipped with AEB active safety function, which can automatically stop or avoid when encountering obstacles ahead, greatly improving vehicle safety. In the summer test of knowing the car in 2024, AEB active safety test is one of the key subjects. With the help of Wuhan Intelligent Networked Automobile Test Site, the test can simulate the rainy environment at night and test the safety performance of automatic driving of vehicles. Thirty-five popular models including Wenjie M7, Ideality L7, Xiaomi SU7, Changan Qiyuan A07, Aouita 12, BMW i5, Wangwang U8 and Qin L DM-i participated in the test.

According to the test rules, the test vehicle will go to the rainy night road with stationary obstacle ahead at the speed of 60/70/80km/h to test whether it can successfully avoid or stop in time, and give drivers and other traffic participants danger tips and corresponding protection.

The results show that among all the 35 vehicles tested, 16 vehicles passed the 60/70/80km/h interval test, accounting for 45.7%. Except Volvo EM90, all the others were domestic new energy vehicles.

There are 7 models that have passed the test at 80km/h, namely: Wenjie M7, Weilai ET5, Aouita 12, Zhijie S7, Wenjie M9, Tengshi N7 and Tucki G6. The first 4 models have taken the initiative to bypass when encountering a faulty car.

Huawei’s four models with ADS PRO V2.0 version: Aouita 12, Wenjie M7, Wenjie M9 and Zhijie S7, have the leading test results. They all passed the test with a speed of 80 km/h. Among them, the M7 has early warning, double flashing and seat belt pretensioning at the same time, which gives drivers, the rear car tips and pre-protection in the car, showing the highest level of intelligent driving in China.

During the test, Know Car Emperor conducted a live broadcast, and invited a number of car companies and industry experts to jointly supervise. Netizens can also ask questions at any time in the live broadcast room. Seeing many wonderful scenes of test vehicles stopping or bypassing in extreme environment, netizens praised the barrage screen.

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